Structural Determinants of the Clostridium Difficile Toxin a Glucosyltransferase Activity*
نویسندگان
چکیده
Background: C. difficile TcdA and TcdB glucosylate small GTPases. Results: Structural and functional studies reveal comparable activities with Rho substrates, enhanced activities following autoprocessing, and TcdA-specific modification of Rap2A. Conclusion: TcdA is a potent enzyme and modifies a broader array of GTPase substrates than TcdB. Significance: These findings highlight the importance of autoprocessing for activity and reveal differences in target specificity between the toxins.
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Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.
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